<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
PS122 PS122 South Africa 2003 HIV1 C PBMC None

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19I, T31A, M36L, N37S, R41K, H69K, L89M, I93L  
>PS122| codons 1-99
PQITLWQRPLVSIKVGGQIKEALLDTGADDAVLEELSLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48E, V90I, K122E, D123G, K166R, K173A, Q174K, T200A, Q207E, R211S, F214L, V245Q, D250E, S251N, A272S, T286A, E291D, V292I, I293V, P313T, Q334C, G335D, R356K, G359T, K366R, T369A, T377L, K390R, A400I, E404D, E413D, V435A, L452I, V466I, T470N, D471E, I482L, H483K, L491S, A502V, S519N, K530R, A534S, A554K  
>PS122| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKIEKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAKNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLSWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKENWTVNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKETVHGVYYDPSKDLIAEIQKQGCDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVRQLAEAVQKIALESIVIWGKTPKFRLPIQKETWEIWWTDYWQATWIPDWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKIGKAGYVTDRGRQKIVSLNETTNQKTELQ
ALKLALQDSGSEVNIVTDSQYVLGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSKGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E10X, D25E, V31I, M50I, F100Y, L101I, T112V, T124S, T125A, K136Q, V201I, T218I, L234I, A265V, R269K, D278A S283G
>PS122| codons 1-288
FLDGIDKAQXEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSSAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008