<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V21I, V35T, E36A, T39E, S48T, V60I, T69S, K122E, D123G, I135V, K173A, Q174K, D177E, T200A, Q207E, R211K, V245Q, A272P, Q278K, T286A, E291D, V292I, I293V, Q334D, G335D, R356K, G359T, T377L, K390R, E396D, A400M, E404D, V435A, A437V, L452M, Y457D, S468P, T470S, D471E, H483Q, L491S, E492K, S519N, K527R, K528R, K530R, A534S, A554N  
>PS088| codons 1-560
PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSSKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKKLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGDDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIALESIVIWGKTPKFRLPIQKDTWEMWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGVETFYVDGAANRETKMGKAGDVTDRGRQKVVPLSETTNQKTELQ
AIQLALQDSGSKVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIRRERVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, I15V, L19V, M36I, R41K, H69K, L89M, I93L  
>PS088| codons 1-99
PQITLWQRPLVSIRVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    S17N, S24A, I72V, F100Y, L101I, T112V, S119P, T124A, T125A, K136Q, V201I, T218I, L234I, A265V, D278A S283G
>PS088| codons 1-288
FLDGIDKAQEEHEKYHNNWRAMAADFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGPN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008