<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, K14R, I15V, L19I, E35D, M36I, R41K, K43R, H69K, L89M, I93L  
>PS026| codons 1-99
PQITLWQRPLVSIRVGGQIKEALLDTGADDTVLEDINLPGKWRPKMIGGIGGFIKVRQYD
QILIEICGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, T39K, S48T, V60I, T69A, K122E, E169D, K173A, Q174K, D177E, T200A, Q207A, F214L, L228P, V245Q, S268C, A272P, L279I, K281R, T286A, E291D, V292I, I293V, D324E, Q334H, G335D, R356K, M357R, G359T, V365I, W383R, K390R, E399D, A400I, E404D, T419A, V435A, L452M, K454R, R461K, V466I, D471E, T477A, H483Q, L491S, S519N, K527N, V531I, A534S, A554K  
>PS026| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICKEMEKEGKITKIGPENPYNTPI
FAIKKKDSAKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILDPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELRAHLLRWGLTTPDKKHQKEPPFPWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWACQIYPGIKVKQICRLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDIKQLTEAVQKIATESIVIRGKTPKFRLPIQKETWDIWWTDYWQATWIPEWEFVNAP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKMGRAGYVTDKGRQKIVSLTETTNQKAELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLINKEKIYLSWVPAHK
GIGGNEQVDKLVSKGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D6E, E13D, S17N, D25E, V31I, M50I, F100Y, L101I, T112V, T124A, T125A, K136Q, V201I, T218I, N222S, L234I, K240R, A265V, R269K, D278A S283G
>PS026| codons 1-288
FLDGIEKAQEEHDKYHNNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQSFRVYYRDSRDPIWKGPAR
LLWKGEGAVVIQDNSDIKVVPRRKVKIIKDYGKQMAGADCVAGRQDED

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008