<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11D, Y15H, S24N, D25E, V31I, L45I, I72V, V88X, F100Y, L101I, T112V, T125A, K136Q, V201I, I203M, T218I, L234I, N254S, A265V, R269K, D278A  
>1214| codons 1-288
FLDGIDKAQEDHEKHHSNWRAMANEFNLPPIVAKEIVASCDKCQIKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEXIPAETGQETAYYILKLAGRWPVKVIHTDNGSN
FTSTAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDMIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDSSDIKVVPRRKVKIIKDYGKQMAGADCVASRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  M46V T12S, I15V, L19T, E35D, M36I, R41K, L63V, H69K, T74S, L89M, I93L  
>1214| codons 1-99
PQITLWQRPLVSIKVGGQTKEALLDTGADDTVLEDINLPGKWKPKVIGGIGGFIKVRQYD
QIVIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, K102Q, K122E, D123N, K173T, Q174R, T200A, Q207E, R211K, F214L, V245H, D250E, L283I, E291D, V292I, I293V, I329L, Q334H, G335D, G359T, A376T, T377M, K390R, E396D, A400T, E404D, V435A, E449D, L452I, V466I, S468P, D471E, H483Q, L484I, L491P, Q507H, A508G, Q509L, S519N, K527N, K530R, A534S, A554R  
>1214| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKQKKSVTVLDVGDAYFSVPL
DENFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTRNPDIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIHLPEKESWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIRGTKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAELQKQGHDQWTYQIYQEPFKNLKTGKYARMRTA
HTNDVKQLTEAVQKITMESIVIWGKTPKFRLPIQKDTWETWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRDTKIGKAGYVTDRGRQKIVPLTETTNQKTELQ
AIQIALQDSGPEVNIVTDSQYALGIIHGLPDKSESELVNQIIEQLINKERVYLSWVPAHK
GIGGNEQVDKLVSRGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008