Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P132 | P132-20 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, M184V, T215F | K219Q | L100I, K103N | K20R, E28K, K102R, K122E, D123E, I135T, G196E, L228H |
| >P132-20| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-20| D02 | codons 1-229 | clone D02 PISPIETVPVKLKPGMDGPRVK*WPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVPDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQHNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIKELRQHLLRWGFFTPDQKHQKEPPFHW >P132-20| D01 | codons 1-229 | clone D01 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNRRTQDFWEVQLGIPHPAGLEKNKSVTILDVCDAYFSVPL DPEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFLW >P132-20| D03 | codons 1-229 | clone D03 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIKELRQHLLRWGFFTPDQKHQKEPPFHW >P132-20| D05 | codons 1-229 | clone D05 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKLSKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-20| D08 | codons 1-229 | clone D08 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEREGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-20| D06 | codons 1-229 | clone D06 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPRGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-20| D07 | codons 1-229 | clone D07 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGPPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW >P132-20| D04 | codons 1-229 | clone D04 PISPIETVPVKLKPGMDGPRVKQWPLTKEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPDQKHQKEPPFHW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, T12I, I13V, G16E, M36I, I62V, L63A |
| >P132-20| D06 | codons 1-99 | clone D06 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-20| D07 | codons 1-99 | clone D07 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-20| D04 | codons 1-99 | clone D04 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEVNLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTSVNIIGRNLLTQIGCTLNF >P132-20| D03 | codons 1-99 | clone D03 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-20| D01 | codons 1-99 | clone D01 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-20| D08 | codons 1-99 | clone D08 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-20| D02 | codons 1-99 | clone D02 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-20| D05 | codons 1-99 | clone D05 PQITLWQRPIVKVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P132-20| codons 1-99 PQITLWQRPIVIVKIEGQLKEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QVAIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |