<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
  V11I T12S, I15V, L19T, E35D, M36I, R41K, K45R, L63P, H69K, V82I, L89I, I93L  
>1134| codons 1-99
PQITLWQRPLISIKVGGQTKEALLDTGADDTVLEDINLPGKWKPRMIGGIGGFIKVRQYD
QIPIEICGKKAIGTVLVGPTPINIIGRNILTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
  V75A     K20R, V35T, E36A, T39D, S48T, K104R, K122E, D123S, I135T, K166R, K173A, Q174K, D177E, T200A, Q207E, V245Q, A272S, K277R, T286A, E291D, V292I, I293V, D324N, Q334H, G335D, R356K, G359T, A376G, T377L, K385R, T386I, K390R, A400I, E404D, V435A, L452I, R461K, R463K, T470S, D471E, T477A, H483Q, L491S, S519N, K530R, A534S, A554K  
>1134| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTAICDEMEKEGKITKIGPENPYNTPV
FAIKKKDSTKWRKLADFRELNKRTQDFWEVQLGIPHPAGLKKKRSVTVLDVGDAYFSVPL
DESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRAKNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTVNDIQKLVGKLNWASQIYSGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKNLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKMRTA
HTNDVKQLTEAVQKIGLESIVIWGRIPKFRLPIQKETWEIWWTDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRETKIGKAGYVTDKGKQKVVSLSETTNQKAELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKERVYLSWVPAHK
GIGGNEQVDKLVSKGIRKVL

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    E11G, E13G, D25E, S39N, L45Q, M50I, I72V, I84V, F100Y, L101V, T112V, T124A, T125A, K136Q, V201I, T218I, L234I, E246G, D278A S283G
>1134| codons 1-288
FLDGIDKAQEGHGKYHSNWRAMASEFNLPPVVAKEIVANCDKCQQKGEAIHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYVEAEVIPAETGQETAYYVLKLAGRWPVKVIHTDNGSN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGGGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGADCVAGRQDED

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008