<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    D25E, K34R, L63V, I72V, L74I, H78R, V79A, F100Y, L101I, K103R, T112V, S119T, T124A, T125A, K136Q, V201I, L234I, D270E, D278A S283G
>1119| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASEFNLPPVVAREIVASCDKCQLKGEAMHGQVDCSPGI
WQVDCTHLEGKVIIVAVRAASGYIEAEVIPAETGQETAYYILRLAGRWPVKVIHTDNGTN
FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDIQTKELQKQITKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIREYGKQMAGADCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    T12S, I15V, L19V, M36I, R41K, L63V, H69K, T74S, L89M, I93L  
>1119| codons 1-99
PQITLWQRPLVSIKVGGQVKEALLDTGADDTVLEEINLPGKWKPKMIGGIGGFIKVRQYD
QIVIEICGKKAIGSVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, S48T, V60I, K122E, D123G, A158S, K173A, D177E, I178M, T200A, Q207E, R211K, V245Q, D250G, K277R, T286A, E291D, V292I, I293V, Q334H, G335D, R356K, M357R, G359T, K366R, T369A, T377M, K390R, A400T, W402R, E404D, W406R, P421X, V435A, A437V, A446S, L452I, S468T, L469I, H483Q, L491S, K512N, L517I, S519N, Q524E, K530R, A534S, A554S Y232S
>1119| codons 1-560
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAQNPEMVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGSELHPDKWT
VQPIQLPEKGSWTVNDIQKLVGKLNWASQIYAGIKVRQLCKLLRGAKALTDIVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGHDQWTYQIYQEPFKNLKTGKYAKRRTA
HTNDVRQLAEAVQKIAMESIVIWGKTPKFRLPIQKETWETWRTDYRQATWIPEWEFVNTP
XLVKLWYQLEKEPIAGVETFYVDGASNRETKIGKAGYVTDRGRQKVVTITDTTNQKTELQ
AIQLALQDSGSEVNIVTDSQYALGIIQAQPDNSESEIVNQIIEELIKKERVYLSWVPAHK
GIGGNEQVDKLVSSGIRKVL

References
Author Title Citation
Matthews, PC Central role of reverting mutations in HLA associations with human immunodeficiency virus set point. J Virol, 2008