Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P122 | P122-31 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 31 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | K103N | P225H | K20R, F214L |
| >P122-31| H09 | codons 1-229 | clone H09 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEHPFLW >P122-31| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEHPFLW >P122-31| H06 | codons 1-229 | clone H06 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFREQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEHPFLW >P122-31| H11 | codons 1-229 | clone H11 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLNKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEHPFLW >P122-31| H10 | codons 1-229 | clone H10 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETSGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEHPFLW >P122-31| H04 | codons 1-229 | clone H04 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLNKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLW >P122-31| H05 | codons 1-229 | clone H05 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSNMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEHPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, K14R, I62V, L63S, H69R, V77I | P39I |
| >P122-31| codons 1-99 PQITLWQRPLVSIRIGGQLKEALLDTGADDTVLEEMNLIGRWKPKMIGGIGGFIKVRQYD QVSIEICGRKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P122-31| H06 | codons 1-99 | clone H06 PQITLWQRPLVSIRIGGQLKEALLDTGAGDTVLEEMNLIGRWKPKMIGGIGGFIKVRQYD QVSIEICGRKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P122-31| H05 | codons 1-99 | clone H05 PQITLWQRPLVSIRIGGQLKEALLDTGADDTVLEEMNLAGRWKPKMIGGIGGFIKVRQYD QVTIEICGRKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P122-31| H11 | codons 1-99 | clone H11 PQITLWQRPLVSIRIGGQLKEALLDTGADDTVLEEMNLIGRWKPKMIGGIGGFIKVRQYD QVSIEICGRKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P122-31| H09 | codons 1-99 | clone H09 PQITLWQRPLVSIKIGGQLKEALLDTGADDTVLEEMDLTGRWKPKMIGGIGGFIKVRQYD QVTIEICGRKAIGTVLIGPTPVNIIRRNLLTQIGCTLNF >P122-31| H04 | codons 1-99 | clone H04 PQITLWQRPLVSIRIGGQLKEALLDTGADDTVLEEMNLIGRWKPKMIGGIGGFIKVRQYD QVSIEICGRKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF >P122-31| H10 | codons 1-99 | clone H10 PQITLWQRPLVSIRIGGQLKEALLDTGADDTVLEEMNLTGRWKPKMIGGIGGFIKVRQYD QVTIEICGRKAIGTILIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |