Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P117 | P117-82 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 82 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | A98G | I50V, K64R, V90I, D123E, I135V, S162A, Q197R, R211K |
| >P117-82| D02 | codons 1-229 | clone D02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKVGPENPYNTPV FAIRKKDSTRWRKLVDFRELNKRTQDFWEIQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGRHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW >P117-82| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKVGPENPYNTPV FAIRKKDSTRWRKLVDFRELNKRTQDFWEIQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGRHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37G, L63T, I72T, V77I | T31A |
| >P117-82| D02 | codons 1-99 | clone D02 PQITLWQRPLVTIKIGGQLKEALLDTGADDAVLEEMGLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKATGTVLIGPTPVNIIGRNLLTQIGCTLNF >P117-82| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDAVLEEMGLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKATGTVLIGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |