Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P115 | P115-20 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | K103N | P4S, V10A, K101Q, I135V, G196E, R211G | E29K, E42K |
| >P115-20| codons 1-229 PISSIETVPAKLKPGMDGPKVKQWPLTEKKIKALVEICTEMKKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLGWGFTTPDKKHQKEPPFLW >P115-20| G05 | codons 1-229 | clone G05 PISSIETVPAKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLGWGFTTPDKKHQKEPPFLW >P115-20| G04 | codons 1-229 | clone G04 PISSIETVPAKLKPGMDGPKVKQWPLTEKKIKALVEICTEMKKEGKISKIGPENPYNTPV FAIKKKDSTR*KKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLGWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L19I, M36V, N37H, L63R, K70E |
| >P115-20| G04 | codons 1-99 | clone G04 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEVHLPGRWKPKMIGGIGGFIKVRQYD QIRIEICGQEAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P115-20| G05 | codons 1-99 | clone G05 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEMHLPGRWKPKMIGGIGGFIKVRQYD QIRIEICGHEAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P115-20| codons 1-99 PQITLWQRPLVTIKIGGQIKEALLDTGADDTVLEEVHLPGRWKPKMIGGIGGFIKVRQYD QIRIEICGHEAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |