Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P115 | P115-2 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 2 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | V10A, K11R, V90I, I135V, G196E, R211G | E29G |
| >P115-2| codons 1-229 PISPIETVPARLKPGMDGPKVKQWPLTEGKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLGWGFTTPDKKHQKEPPFLW >P115-2| A04 | codons 1-229 | clone A04 PISPIETVPARLKPGMDGPKVKQWPLTEGKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLGWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V11A, L19I, N37H, L63R, K70E |
| >P115-2| codons 1-99 PQITLWQRPLATIKIGGQIKEALLDTGADDTVLEEMHLPGRWKPKMIGGIGGFIKVRQYD QIRIEICGHEAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P115-2| A04 | codons 1-99 | clone A04 PQITLWQRPLATIKIGGQIKEALLDTGADDTVLEEMHLPGRWKPKMIGGIGGFIKVRQYD QIRIEICGHEAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |