Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P113 | P113-20 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | Y188L | D123E, I135T, S162C, D177E, Q207E | K82E, V111A, F130S, W153R, H221R |
| >P113-20| B01 | codons 1-229 | clone B01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNERTQDFWEVQLGIPHPAGLKKKKSVTVLDAGDAYFSVPL DKEFRKYTASTIPSTNNETPGIRYQYNVLPQGRKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLLVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKRQKEPPFLW >P113-20| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNERTQDFWEVQLGIPHPAGLKKKKSVTVLDAGDAYFSVPL DKEFRKYTASTIPSTNNETPGIRYQYNVLPQGRKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLLVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKRQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I15V, I93L |
| >P113-20| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P113-20| B01 | codons 1-99 | clone B01 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |