Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P113 | P113-32 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, M184V | Y188L | D123E, S162C, D177E, Q207E |
| >P113-32| D02 | codons 1-229 | clone D02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLLVGSDLEIGQHRTKIKELREHLLRWGFTTPDKKHQKEPPFLW >P113-32| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLLVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >P113-32| D09 | codons 1-229 | clone D09 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAMFQCSMTKILEPFRKQNPEIVI YQYVDDLLVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >P113-32| D11 | codons 1-229 | clone D11 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLLVGSNLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >P113-32| D07 | codons 1-229 | clone D07 PISPIETVPVKLKPGMDGSKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPRPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNETPGTRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLLVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPFLW >P113-32| D06 | codons 1-229 | clone D06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIEKKDSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYVDDLLVGSDLEIGQHRTKIEELREHLLRWGFTTPDKKHQKEPPLLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I15V, I93L |
| >P113-32| D02 | codons 1-99 | clone D02 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P113-32| D11 | codons 1-99 | clone D11 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIVIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P113-32| D06 | codons 1-99 | clone D06 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P113-32| D07 | codons 1-99 | clone D07 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGDFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P113-32| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P113-32| D09 | codons 1-99 | clone D09 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QILIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |