Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P110 | P110-59 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 43 |
| 3 | 3TC+AZT+EFV+IDV | 16 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R | K219Q | L100I, K103N | V35T, T39A, V60I, T69N, K122E, D123N, I135T, K166R, D177N, T200I, I202V, Q207A, R211K |
| >P110-59| C02 | codons 1-229 | clone C02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSVTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIGQHRIKIDELRAHLLKWGFTAPDQKHQKEPPFLW >P110-59| C06 | codons 1-229 | clone C06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRISEPFRKQNPNIVI YQYMDDLYVGSDLEIGQHRIKIDELRAHLLKWGFTTPDQKHQKEPPFLW >P110-59| C03 | codons 1-229 | clone C03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIVI YQYMDDLYVGSDLEIGQHRLKIEELRAHLLKWGFTTPDQKHQKEPPFLW >P110-59| C07 | codons 1-229 | clone C07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIRPENPYNTPV FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIVI YQYMDDLLVGSDLEIGQHRIKVEELRAHLLKWGLTTPDQKHQKEPPFLW >P110-59| C04 | codons 1-229 | clone C04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKVVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSVTKILEPFRKQNPNIVI YQYMDDLYVGSDLEIGQHRIKIEELRAHLLKWGLTTPDQKHQKEPPFLW >P110-59| C08 | codons 1-229 | clone C08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPSIVI YQYMDDLLVGSDLEIGQHRIKVEELRAHLLKWGFTTPDQKHQKEPPFLW >P110-59| C09 | codons 1-229 | clone C09 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIVI YQYMDDLYVGSDLEIGQHRIKVEELRAHLLKWGFTTPDQKHQKEHPFLW >P110-59| C05 | codons 1-229 | clone C05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIVI YQYMDDLYVGSDLEIRQHRIKVEELRAHLLKWGFTTPDQKHQKEHPFLW >P110-59| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKISKIGPENPYNTPI FAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPNIVI YQYMDDLYVGSDLEIGQHRIKVEELRAHLLKWGFTTPDQKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E35D, M36I, I64V |
| >P110-59| C04 | codons 1-99 | clone C04 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P110-59| C08 | codons 1-99 | clone C08 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMVGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P110-59| C09 | codons 1-99 | clone C09 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P110-59| C06 | codons 1-99 | clone C06 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P110-59| C07 | codons 1-99 | clone C07 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P110-59| C05 | codons 1-99 | clone C05 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDMSLPGRWKPKMVGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P110-59| C03 | codons 1-99 | clone C03 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QILVEICGQKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P110-59| C02 | codons 1-99 | clone C02 PQITLWQRPLVTIKIGGQLKEALLDTGADDTALEDINLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P110-59| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYD QILVEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |