Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB4-P102 | P102-22 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 8 |
| 2 | 3TC+AZT+EFV | 22 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | L100I, K103N | K20R, K43Q, E44D, V118I, D123E, I135T, Y146H, D177E, G196E, E203K, Q207E, R211Q | N57S |
| >P102-22| G10 | codons 1-229 | clone G10 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYSTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQHNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW >P102-22| codons 1-229 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYSTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQHNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIKELREHLWQWGFYTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, L19P, N37H, R41K, L63T, I64V, I85T, I93L |
| >P102-22| G10 | codons 1-99 | clone G10 PQITLWQRPIVTIKIGGQPKEALLDTGADDTVLEEMHLPGKWKPKMIGGIGGFIKVRQYD QITVEICGHKAIGTVLVGPTPVNITGRNLLTQLGCTLNF >P102-22| codons 1-99 PQITLWQRPIVTIKIGGQPKEALLDTGADDTVLEEMHLPGKWKPKMIGGIGGFIKVRQYD QITVEICGHKAIGTVLVGPTPVNITGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |