<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P93 P93-63 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI NA
2 IDV 2
3 EFV+IDV 61

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
D67N, T69D, K70R K219Q K103N P225H V35T, V60I, V90I, D123E, I135T, D177E, I178V, G196E, E204K, Q207E  
>P93-63| D01 | codons 1-229 | clone D01
PISPIETVPVKLKPGMDGPKVEQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVII
YQYIDDLYVSSDLEIGQHRAKIEKLREHLSRWGFTTPDQKHQKEHPFLW
>P93-63| D06 | codons 1-229 | clone D06
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLPKNKSVTVLDVGDAYFSIPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI
YQYMDDLYVGSDLEIEQHRTKIEKLREHLLRWGFTTPDQKHQKEPPFLW
>P93-63| D12 | codons 1-229 | clone D12
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI
YQYMDDLYVGSDLEIEQHRTKIEKLREHLLRWGFTTPDQKHQKEHPFLW
>P93-63| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI
FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI
YQYMDDLYVGSDLEIEQHRTKIEKLREHLLRWGFTTPDQKHQKEHPFLW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I15V, G16E, E35D, N37K, P39S, R41K, I62V, L63P, I93L  
>P93-63| D12 | codons 1-99 | clone D12
PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEDMKLSGKWKPKMIGGVGGFIKVRQYD
QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P93-63| D01 | codons 1-99 | clone D01
PQITLRQRPLVTIKVEGQLKEALLDTGADDTVLEDIKLSGKWKPKMIGGIGGFIKVRQYD
QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF
>P93-63| D06 | codons 1-99 | clone D06
PQITLWQRPIVTIKVEGHLKEALLDTGADDTVLEDMKLSGKWKPKMIGGIGGFIKVKQYD
QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P93-63| codons 1-99
PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEDMKLSGKWKPKMIGGIGGFIKVRQYD
QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005