Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P93 | P93-63 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 61 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R | K219Q | K103N | P225H | V35T, V60I, V90I, D123E, I135T, D177E, I178V, G196E, E204K, Q207E |
| >P93-63| D01 | codons 1-229 | clone D01 PISPIETVPVKLKPGMDGPKVEQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVII YQYIDDLYVSSDLEIGQHRAKIEKLREHLSRWGFTTPDQKHQKEHPFLW >P93-63| D06 | codons 1-229 | clone D06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLPKNKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIEQHRTKIEKLREHLLRWGFTTPDQKHQKEPPFLW >P93-63| D12 | codons 1-229 | clone D12 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIEQHRTKIEKLREHLLRWGFTTPDQKHQKEHPFLW >P93-63| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSDRWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEVVI YQYMDDLYVGSDLEIEQHRTKIEKLREHLLRWGFTTPDQKHQKEHPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, G16E, E35D, N37K, P39S, R41K, I62V, L63P, I93L |
| >P93-63| D12 | codons 1-99 | clone D12 PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEDMKLSGKWKPKMIGGVGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P93-63| D01 | codons 1-99 | clone D01 PQITLRQRPLVTIKVEGQLKEALLDTGADDTVLEDIKLSGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >P93-63| D06 | codons 1-99 | clone D06 PQITLWQRPIVTIKVEGHLKEALLDTGADDTVLEDMKLSGKWKPKMIGGIGGFIKVKQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P93-63| codons 1-99 PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEDMKLSGKWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |