<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P92 P92-0 U.S. 1998 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L210W T215D     V35M, T39A, E40D, S68G, K122E, T139M, Q174E  
>P92-0| F04 | codons 1-229 | clone F04
PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV
FAIKKKDTTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNEMPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW
>P92-0| F02 | codons 1-229 | clone F02
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW
>P92-0| F05 | codons 1-229 | clone F05
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW
>P92-0| F07 | codons 1-229 | clone F07
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNEMPGNRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW
>P92-0| F01 | codons 1-229 | clone F01
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEREGKISKIGPENPYNTPV
FAIKKKDTTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNEMPGIRYQYNMLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW
>P92-0| F08 | codons 1-229 | clone F08
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV
FAIKKKDTTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDRKHQKEPPFLW
>P92-0| F03 | codons 1-229 | clone F03
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGPDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW
>P92-0| F06 | codons 1-229 | clone F06
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW
>P92-0| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV
FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    N37S, R41K, L63C  
>P92-0| F03 | codons 1-99 | clone F03
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P92-0| F02 | codons 1-99 | clone F02
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P92-0| F06 | codons 1-99 | clone F06
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P92-0| F07 | codons 1-99 | clone F07
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLKKMSLPGKWKPKIIGEIGSFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P92-0| F04 | codons 1-99 | clone F04
PQITLWQRPLVTIKIGEQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P92-0| F05 | codons 1-99 | clone F05
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P92-0| F01 | codons 1-99 | clone F01
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P92-0| F08 | codons 1-99 | clone F08
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
>P92-0| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD
QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005