Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P92 | P92-0 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L210W | T215D | V35M, T39A, E40D, S68G, K122E, T139M, Q174E |
| >P92-0| F04 | codons 1-229 | clone F04 PISPIETIPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKDTTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGTRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW >P92-0| F02 | codons 1-229 | clone F02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW >P92-0| F05 | codons 1-229 | clone F05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW >P92-0| F07 | codons 1-229 | clone F07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGNRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW >P92-0| F01 | codons 1-229 | clone F01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAELEREGKISKIGPENPYNTPV FAIKKKDTTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNMLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW >P92-0| F08 | codons 1-229 | clone F08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV FAIKKKDTTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDRKHQKEPPFLW >P92-0| F03 | codons 1-229 | clone F03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGPDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW >P92-0| F06 | codons 1-229 | clone F06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEGFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW >P92-0| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICADLEKEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKENPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLWRWGFDTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| N37S, R41K, L63C |
| >P92-0| F03 | codons 1-99 | clone F03 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P92-0| F02 | codons 1-99 | clone F02 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEISLPGKWKPKMIGGIGGFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P92-0| F06 | codons 1-99 | clone F06 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P92-0| F07 | codons 1-99 | clone F07 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLKKMSLPGKWKPKIIGEIGSFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P92-0| F04 | codons 1-99 | clone F04 PQITLWQRPLVTIKIGEQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P92-0| F05 | codons 1-99 | clone F05 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P92-0| F01 | codons 1-99 | clone F01 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P92-0| F08 | codons 1-99 | clone F08 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P92-0| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGKWKPKMIGGIGGFIKVRQYD QICIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |