Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P89 | P89-96 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV+IDV | 96 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K101E, G190S | K122P, S162C, T200A |
| >P89-96| B08 | codons 1-229 | clone B08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPHNTPV FAIKKKDSTKWRKLVDFRELNKGTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLHVSSDLEIGQHRAKIEELRQHLLRWGFYTPDKKHQKEPPFLW >P89-96| B06 | codons 1-229 | clone B06 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTK*RKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRAKIEELRQHLLRWGFYTPDKKHQKEPPFLW >P89-96| B05 | codons 1-229 | clone B05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DPEFRKYTAFTIPSINNETPGIRHQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P89-96| B04 | codons 1-229 | clone B04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P89-96| B03 | codons 1-229 | clone B03 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P89-96| B02 | codons 1-229 | clone B02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIRALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHSAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRAKIEELRQHLLRWGFYTPDKKHQKEPPFLW >P89-96| B01 | codons 1-229 | clone B01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P89-96| B07 | codons 1-229 | clone B07 PISSIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPNINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P89-96| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DPDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82T, L90M | L10F | K43R, L63P, A71I, I72T, I93L |
| >P89-96| B04 | codons 1-99 | clone B04 PQITLWQRPVVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWRPKIIGGIGGFIKVRQYD QIPIEICGHKTTGTVLVGPTPTNIIGRNLMTQLGCTLNF >P89-96| B01 | codons 1-99 | clone B01 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKTTGTVLVGPTPTNIIGRNLMTQLGCTLNF >P89-96| B02 | codons 1-99 | clone B02 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD QIPIEICGHKITGTVLVGPTPVNIIGRNLLTQLGCTLNF >P89-96| B07 | codons 1-99 | clone B07 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD QIPMEICGHKITGTVLVGPTPTNIIGRNLMTQIGCTLNF >P89-96| B06 | codons 1-99 | clone B06 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD QIPTEICGHKITGTVLVGPTPTNIIGRNLMTQIGCTLNF >P89-96| B05 | codons 1-99 | clone B05 PQITLWQRPLVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWRPKIIGGIGGFIKVRQYD QIPIEICGHKTTGTVLVGPTPTNIIGRNLLTQLGCTLNF >P89-96| B03 | codons 1-99 | clone B03 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD QIPIEICGHKITGTVLVGPTPTNIIGRNLMTQIGCTLNF >P89-96| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWRPKMIGGIGGFIKVRQYD QIPIEICGHKITGTVLVGPTPTNIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |