<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
LB3-P84 P84-84 U.S. 1997 HIV1 B Plasma MMC

Treatment History
Order Regimen Weeks
1 NRTI NA
2 IDV 2
3 EFV+IDV 82

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   Y188L   K32N, I135T, R211K  
>P84-84| A07 | codons 1-229 | clone A07
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYSTPV
FAIKEKDSTKWRKLVDFRELNKRTQDFWGVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW
>P84-84| A06 | codons 1-229 | clone A06
PISPIETVPVKLRPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW
>P84-84| A04 | codons 1-229 | clone A04
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW
>P84-84| A01 | codons 1-229 | clone A01
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVT
YQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW
>P84-84| A03 | codons 1-229 | clone A03
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW
>P84-84| A08 | codons 1-229 | clone A08
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNAPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKISEPFRKQNPDIII
YQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW
>P84-84| A05 | codons 1-229 | clone A05
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVGDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW
>P84-84| A09 | codons 1-229 | clone A09
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINVLVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW
>P84-84| codons 1-229
PISPIETVPVKLKPGMDGPKVKQWPLTEEKINALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYVDDLLVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLW

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, L76V   T12S, L19I, E35D, N37D, L63P, I64V, I93L  
>P84-84| A07 | codons 1-99 | clone A07
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF
>P84-84| A01 | codons 1-99 | clone A01
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF
>P84-84| A04 | codons 1-99 | clone A04
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF
>P84-84| A03 | codons 1-99 | clone A03
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF
>P84-84| A06 | codons 1-99 | clone A06
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QVPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF
>P84-84| A09 | codons 1-99 | clone A09
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF
>P84-84| A05 | codons 1-99 | clone A05
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF
>P84-84| A08 | codons 1-99 | clone A08
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF
>P84-84| codons 1-99
PQITLWQRPLVSIKIGGQIKEALLDTGADDTVLEDMDLPGRWKPKIIGGIGGFIKVRQYD
QIPVEICGHKAIGTVVVGPTPVNIIGRNLLTQLGCTLNF

References
Author Title Citation
Bacheler, LT Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. AAC, 2000
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005