Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P77 | P77-109 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 107 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V, T215Y | K103N | V108I | V35I, E53D, K166T, Q207E, R211K, E224N, L228V | K220N |
| >P77-109| F05 | codons 1-229 | clone F05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTTILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKKHQKEPPFLW >P77-109| F08 | codons 1-229 | clone F08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPDNPYNTPV FAIKKKDSTKWKKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTTILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKNIRKNPHSVG >P77-109| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALIEICTEMEKEGKISKIGPDNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTTILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRTKIEELREHLLKWGFYTPDKNHQKNPPFVW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, V82A | L24I | L10I, K55R, I62V, L63P, T74S, V77I, I93L |
| >P77-109| F05 | codons 1-99 | clone F05 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVRQYD QVQIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P77-109| F08 | codons 1-99 | clone F08 PQITLWQRPIVTMKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVRQYD QVPIEICGHKATGSVLIGPTPANIIGRNLLTQLGCTLNF >P77-109| codons 1-99 PQITLWQRPIVTIKIGGQLKEALIDTGADDTVLEEMNLPGRWKPKIIGGIGGFIRVRQYD QVPIEICGHKAIGSVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |