Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P70 | P70-44 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 42 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | P225H | V21I, I135L, S162C, E169D, D177E, G196E | K122S |
| >P70-44| G04 | codons 1-229 | clone G04 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSATVLDVGDAYFSVPL DSDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P70-44| G01 | codons 1-229 | clone G01 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DSDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P70-44| G03 | codons 1-229 | clone G03 PISPTETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DSDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P70-44| G05 | codons 1-229 | clone G05 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DSDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P70-44| G06 | codons 1-229 | clone G06 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DSDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIEQHKTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P70-44| G02 | codons 1-229 | clone G02 PISPIETIPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DSDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P70-44| G07 | codons 1-229 | clone G07 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIEALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DSDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P70-44| codons 1-229 PISPIETVPVKLKPGMDGPKIKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DSDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILDPFRKQNPEIVI YQYMDDLYVGSDLEIEQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10I, R41K, I62V, L63P, I93L |
| >P70-44| G07 | codons 1-99 | clone G07 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QIPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >P70-44| G01 | codons 1-99 | clone G01 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >P70-44| G03 | codons 1-99 | clone G03 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >P70-44| G05 | codons 1-99 | clone G05 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >P70-44| G06 | codons 1-99 | clone G06 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >P70-44| G02 | codons 1-99 | clone G02 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >P70-44| G04 | codons 1-99 | clone G04 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF >P70-44| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QVPIEICGHKAIGTVLVGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. | J Infect Dis, 2005 |