<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 31

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M184V   K103N   K20R, T165L, I178M, R211K, F214L, V245A, A272P, A288S, I293V, A327V, G335D, N348T, M357T, A360AT, T369A, A376T, K390R, E399D, A400T, T403S, V435I, G436E, L452E, V466I, V467VI, H483Y, K512R, S519C, V548I, A554K, K558R  
>161337Ib| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL
DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMLKILEPFRKQNPDMVI
YQYVDDLYVGSDLEIGQHRTKIEELRQHLLKWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIALPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKSLTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIVEIQKQGQDQWTYQIYQEPFKTLKTGKYARTRGT
HTNDVKQLAEAVQKITTESIVIWGKTPKFRLPIQKETWDTWWSEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIIEAETFYVDGAANRETKEGKAGYVTDRGRQKIISLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDRSESELVCQIIEQLIKKEKVYLAWVPAHK
GIGGNEQIDKLVSKGIRRVL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L63A, H69Q  
>161337Ib| codons 1-99
PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD
QIAIEICGQKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Riddler, SA Class-sparing regimens for initial treatment of HIV-1 infection. N Engl J Med, 2008
Brehm, JH Failure of initial therapy with two nucleosides and efavirenz is not associated with early emergence of mutations in the C-terminus of HIV-1 reverse transcriptase. JAIDS, 2011