<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 3TC+D4T+EFV 49
2 None 7

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        E6ED, V8VI, S48T, V60I, A98S, K101R, K122E, I135T, K166R, G196E, T200A, Q207E, V245Q, A272P, I293V, D324DE, K350R, M357MT, A360T, K366R, T377R, A400T, T403I, E404D, V435A, T450TS, R461K, S468N, K476Q, I482V, H483Y, G490E, A502V, K512Q, E514D, E516A, A554S V254VI
>362263Bb| codons 1-560
PISPIDTIPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPSGLRKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTRILEPFRKQNPDIVI
YQYMDDLYVGSDLEIEQHRAKIEELREHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLPEKDSWTINDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEAE
LELAENREILKEPVHGVYYDPSKELIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARTRGT
HTNDVRQLTEAVQKIARESIVIWGKTPKFKLPIQKETWETWWIDYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIAGAETFYVDGAANRESKLGKAGYVTDKGRQKVVNLTDTTNQQTELQ
AVYLALQDSELEVNIVTDSQYVLGIIQAQPDQSDSALVSQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSSGIRKVL

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    I13V, I15V, Q18QE, R41K, K55R, I64V, V77I  
>362263Bb| codons 1-99
PQITLWQRPLVTVKVGGELKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFIRVRQYD
QILVEICGHKAIGTVLIGPTPVNIIGRNLLTQIGCTLNF

References
Author Title Citation
Riddler, SA Class-sparing regimens for initial treatment of HIV-1 infection. N Engl J Med, 2008
Brehm, JH Failure of initial therapy with two nucleosides and efavirenz is not associated with early emergence of mutations in the C-terminus of HIV-1 reverse transcriptase. JAIDS, 2011