Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB5-P159 | P159-32 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT+EFV | 32 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| G190A | D121Y, K122E, I135T, L210F, R211K |
| >P159-32| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLFKWGFTTPDKKHQKEPPFLW >P159-32| E01 | codons 1-229 | clone E01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLFKWGFTTPDKKHQKEPPFLW >P159-32| E02 | codons 1-229 | clone E02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YRYMDDLYVASDLEIGQHRTKIEELRQHLFKWGFTTPDKKHQKEPPFLW >P159-32| E07 | codons 1-229 | clone E07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLFKWGFTTPDKKHQKEPPSLW >P159-32| E05 | codons 1-229 | clone E05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDNTKWRKLVDFRELNKRTQDFWEVQLGIPRPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLFKWGSTTPDKKHQKEPPFLW >P159-32| E04 | codons 1-229 | clone E04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLFKWGFTTPDKKHQKEPPFLW >P159-32| E03 | codons 1-229 | clone E03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKKGKISKIGPENPYNTPV FAIKKKDSTKWRRLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL YEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVASDLEIGQHRTKIEELRQHLFKWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12P, K14R, G16E, W42Y, I62V, L63P, V77I, I93L |
| >P159-32| E03 | codons 1-99 | clone E03 PQITLWQRPLVPIRIEGQLKEALLDTGADDTVLEEMNLPGRYKPKMIGGIGGFIKVRQYD QVPIEVCGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P159-32| E01 | codons 1-99 | clone E01 PQITLWQRPLVPIRIEGQLKEALLDTGADDTVLEEMNLPGRYKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P159-32| E02 | codons 1-99 | clone E02 PQITLWQRPLVPIRIEGQLKEALLDTGADDTVLEEMNLPGRYKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P159-32| E07 | codons 1-99 | clone E07 PQITLWQRPLVPIRIEGQLKEALLDTGADDTVLEEMNLPGRYKPKMIGGIGGFIKVRQYD QVPIEVCGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P159-32| E04 | codons 1-99 | clone E04 PQITLWQRPLVPIRIEGQLKEALLDTGADDTVLEEMNLPGRYKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P159-32| E05 | codons 1-99 | clone E05 PQITLWQRPLVPIRIEGQLKEALLDTGADDTVLEEMNLPGRYKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF >P159-32| codons 1-99 PQITLWQRPLVPIRIEGQLKEALLDTGADDTVLEEMNLPGRYKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLIGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |