Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB5-P158 | P158-56 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT+ EFV | 56 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | K101E, K103N, G190S | V35T, T39A, S48E, I135R, S162A, T200A |
| >P158-56| A06 | codons 1-229 | clone A06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGRIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKNFRKYTASTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P158-56| A07 | codons 1-229 | clone A07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P158-56| A08 | codons 1-229 | clone A08 PISPIETVPVKLKPGMDGPKAKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DKNFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKNHQKEPPFLW >P158-56| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P158-56| A01 | codons 1-229 | clone A01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSITVLDVGDAYFSVPL DKDFRKYTAFTMPSRNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPSLW >P158-56| A02 | codons 1-229 | clone A02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P158-56| A03 | codons 1-229 | clone A03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLQKNKSVTVLDVGDAYFSVPL DKNFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIGELRQHLLRWGFTTPDKKHQKEPPFLW >P158-56| A05 | codons 1-229 | clone A05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLEKKKSVTVLDVGDAYFSVPL DKDFRKYTPFTIPSRNNETPGIRYQYNVPPQGWKGSPAIFQASMTKILEPFRKQNPDIVI YQYVDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P158-56| A04 | codons 1-229 | clone A04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTEICAEMEKEGKIEKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSRNNETPGIRYQYNVLPQGWKGSPAIFQASMTKILEPFRKHNPDIVI YQYVDDLYVSSDLEIGQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| Q18L, L63P |
| >P158-56| codons 1-99 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P158-56| A07 | codons 1-99 | clone A07 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P158-56| A02 | codons 1-99 | clone A02 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P158-56| A03 | codons 1-99 | clone A03 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGRTLNF >P158-56| A04 | codons 1-99 | clone A04 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P158-56| A06 | codons 1-99 | clone A06 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P158-56| A08 | codons 1-99 | clone A08 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P158-56| A01 | codons 1-99 | clone A01 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF >P158-56| A05 | codons 1-99 | clone A05 PQITLWQRPLVTIKIGGLLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |