<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 None NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    L10I, K14R, I15V, K20R, M36I, N37K, R41N, K45R, L63T, C67E, H69K, L89M, I93L  
>SC126| codons 1-99
PQITLWQRPIVTIRVGGQLREALLDTGADDTVLEEIKLPGNWKPRMIGGIGGFIKVRQYD
QITIEIEGKKAIGTVLVGPTPVNIIGRNMLTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        V35T, E36A, T39E, E40D, K43R, S48T, V60I, D121H, K122E, D123S, I142V, K173T, D177E, T200A, Q207E, R211K, V245Q, P247A, E248R  
>SC126| codons 1-249
PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEDMEREGKITKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HESFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRTQNPEIVI
YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIQLARK

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
    V31I, M50I, L101I, T112V, S119P, T124N, G134D, K136Q, V201I, I208L, K211R, T218I, L234I, I251L, D256E, A265V, R269K, D278A  
>SC126| codons 1-288
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI
WQLDCTHLEGKIILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKVIHTDNGPN
FTSNTVKAACWWADIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIIDIIATDLQTRELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVLQDNSEIKVVPRRKVKIIKDYGKQMAGADCVASRQDED

References
Author Title Citation
Graf, T HIV-1 genetic diversity and drug resistance among treatment naive patients from southern Brazil: An association of HIV-1 subtypes with exposure categories. J Clin Virol, 2011