Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P39 | P39-44 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | IDV | 2 |
| 3 | EFV+IDV | 42 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T215Y | G190S | T27S, K43N, I142V, Q207N, R211K |
| >P39-44| F07 | codons 1-229 | clone F07 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIRALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-44| F09 | codons 1-229 | clone F09 PISPIETVPVKLKPGMDGPKAKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQSGIPPPAGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRNHLLEWGFYTPDKKHQKEPPFLW >P39-44| F03 | codons 1-229 | clone F03 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-44| F05 | codons 1-229 | clone F05 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIKELRNHLLKWGFYTPDKKHQKEPPFLW >P39-44| F01 | codons 1-229 | clone F01 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-44| F02 | codons 1-229 | clone F02 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-44| F04 | codons 1-229 | clone F04 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPHNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRY*YNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW >P39-44| F08 | codons 1-229 | clone F08 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPRGWKGSPAISQSSMTKILEPFRKKNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELGNHLLKWGFYTPDKKHQKEPPFLW >P39-44| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLSEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVSSDLEIGQHRTKIEELRNHLLKWGFYTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82T | L10I, N37D, I62V, L63H, V77I, I93L |
| >P39-44| F05 | codons 1-99 | clone F05 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-44| F09 | codons 1-99 | clone F09 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMLGGIGGFIKVRQYD QIPIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-44| F03 | codons 1-99 | clone F03 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-44| F08 | codons 1-99 | clone F08 PQITLWQRPIVTIKIGGQLKEALLDTGAGDTVLEEMDLPGRWKPKMIGGTGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-44| F02 | codons 1-99 | clone F02 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGLIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-44| F07 | codons 1-99 | clone F07 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF >P39-44| F01 | codons 1-99 | clone F01 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGIVLIGPTPTNIIGRNLLTQLGCTLNF >P39-44| F04 | codons 1-99 | clone F04 PQITLWQRPIATIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLAQLGCTLNF >P39-44| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKMIGGIGGFIKVRQYD QVHIEICGHKAIGTVLIGPTPTNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |