Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P28 | P28-44 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 44 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | P225H | K122E, D123E, I135L, S162C, D177E, T200A, Q207E |
| >P28-44| G01 | codons 1-229 | clone G01 PISPIETVPVKLKPGMDGPKVKQWPLTEEEIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEVGQHRAKIEELREHLLRWGFTTPDKRHQKEHPFLW >P28-44| G07 | codons 1-229 | clone G07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYSVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVT YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEHPFLW >P28-44| G08 | codons 1-229 | clone G08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRGLNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEHPFLW >P28-44| G05 | codons 1-229 | clone G05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEHPFLW >P28-44| G04 | codons 1-229 | clone G04 PISPIETVPVKLKPGMDGSKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKGSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEHPFLW >P28-44| G02 | codons 1-229 | clone G02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPS DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLELGQHRAKIEELREHLLRWGFTTPDKKHQKEHPFLW >P28-44| G03 | codons 1-229 | clone G03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEHPFLW >P28-44| G06 | codons 1-229 | clone G06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLKWGFTTPDKKHQKEHPFLW >P28-44| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPEIVI YQYMDDLYVGSDLEIGQHRAKIEELREHLLRWGFTTPDKKHQKEHPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A | L10I, R41K, D60E, L63P, V77I, I93L |
| >P28-44| G06 | codons 1-99 | clone G06 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYE QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P28-44| G07 | codons 1-99 | clone G07 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYE QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P28-44| G01 | codons 1-99 | clone G01 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLVKVRQYE QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P28-44| G08 | codons 1-99 | clone G08 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYE QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P28-44| G04 | codons 1-99 | clone G04 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYE QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P28-44| G02 | codons 1-99 | clone G02 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYE QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P28-44| G05 | codons 1-99 | clone G05 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYK QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P28-44| G03 | codons 1-99 | clone G03 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYE QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF >P28-44| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYE QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |