Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P22 | P22-70 | U.S. | 1998 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 70 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | P225H | K122E, D123E, I135V |
| >P22-70| B03 | codons 1-229 | clone B03 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEHPFLW >P22-70| B07 | codons 1-229 | clone B07 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYPYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P22-70| B01 | codons 1-229 | clone B01 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW >P22-70| B06 | codons 1-229 | clone B06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEKFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P22-70| B08 | codons 1-229 | clone B08 PISPIETVPIKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P22-70| B05 | codons 1-229 | clone B05 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAHFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P22-70| B02 | codons 1-229 | clone B02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEHPFLW >P22-70| B04 | codons 1-229 | clone B04 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSTKWRKLVDFRELNKRTQDFWEIQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P22-70| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSVPL DEEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGFTTPDKKHQKEHPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V82A | F53L | K14R, I15V, R41K, L63P, V77I |
| >P22-70| B01 | codons 1-99 | clone B01 PQITLWQRPLVTIRVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD QIPIEICGHKTIGTVLIGPTPANIIGRNLLTQIGCTLNF >P22-70| B06 | codons 1-99 | clone B06 PQITLWQRPLVTIRVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD QIPIEICGHKTIGTVLIGPTPANIIGRNLLTQIGCTLNF >P22-70| B04 | codons 1-99 | clone B04 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD QIPIEICGHKTIGTVLIGPTPANIIGRNLLTQIGCTLNF >P22-70| B03 | codons 1-99 | clone B03 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGFVKVRQYD QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF >P22-70| B07 | codons 1-99 | clone B07 PQITLWQRPLVTIRVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF >P22-70| B02 | codons 1-99 | clone B02 PQITLWQRPLVTIKVGGQLKEALLDTGADDTVLEEMNLPGKWKPKIIGGIGGLIKVRQYD QILIEIRGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF >P22-70| B05 | codons 1-99 | clone B05 PQITLWQRPLVTIRVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD QIPIEICGHKTIGTVLIGPTPANIIGRNLLTQIGCTLNF >P22-70| B08 | codons 1-99 | clone B08 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD QIPIEICGHKAIGTVLIGPTPANIVGRNLLTQIGCTLNF >P22-70| codons 1-99 PQITLWQRPLVTIRVGGQLKEALLDTGADDTVLEEMNLPGKWKPKMIGGIGGLIKVRQYD QIPIEICGHKAIGTVLIGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |