Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P21 | P21-70 | U.S. | 1997 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 70 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M184V | Y188L | V60I, R83K, V106I, K122E, I135V, S162C, T200I |
| >P21-70| A02 | codons 1-229 | clone A02 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVAICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P21-70| A08 | codons 1-229 | clone A08 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRIKIEELRQHLLRWGLTTPDKKHQKEPPFLW >P21-70| A09 | codons 1-229 | clone A09 PISPIETVPVKLKPEMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGVPHPAGLKKKKSITVLDVGDAYFSVPL DEDFREYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYADDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P21-70| A06 | codons 1-229 | clone A06 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYIVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFFW >P21-70| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSITVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, V82A | L24I | L10I, I15V, L63T, I72V |
| >P21-70| A09 | codons 1-99 | clone A09 PQITLWQRPIVAIKVGGQLKEALIDTGADDTVLEGMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF >P21-70| A08 | codons 1-99 | clone A08 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF >P21-70| A02 | codons 1-99 | clone A02 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF >P21-70| A06 | codons 1-99 | clone A06 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF >P21-70| codons 1-99 PQITLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |