Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| LB3-P21 | P21-16 | U.S. | 1996 | HIV1 | B | Plasma | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | NRTI | NA |
| 2 | EFV | 2 |
| 3 | EFV+IDV | 16 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y188L | V60I, R83K, K122E, I135V, S162C, T200I |
| >P21-16| A13 | codons 1-229 | clone A13 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI LAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNMLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPLFLW >P21-16| A16 | codons 1-229 | clone A16 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P21-16| A15 | codons 1-229 | clone A15 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P21-16| A11b | codons 1-229 | clone A11b PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGRHRIKIEELRQHLLRWGFTTPGKKHQKEPPFLW >P21-16| B06 | codons 1-229 | clone B06 PISPIETVPVTLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTMPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFPW >P21-16| B05a | codons 1-229 | clone B05a PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P21-16| A01h | codons 1-229 | clone A01h PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLIDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P21-16| A02g | codons 1-229 | clone A02g PISPIETVPVKLKPGMDGPKVKQWPLTEEKIEALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P21-16| B07a | codons 1-229 | clone B07a PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVRPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW >P21-16| codons 1-229 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKDSTKWRKLVDFRELNKKTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQCSMTKILEPFRKQNPDIVI YQYMDDLLVGSDLEIGQHRIKIEELRQHLLRWGFTTPDKKHQKEPPFLW |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L63T, I72V |
| >P21-16| A16 | codons 1-99 | clone A16 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| B05a | codons 1-99 | clone B05a PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| A01h | codons 1-99 | clone A01h PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| A15 | codons 1-99 | clone A15 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEETNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| B07a | codons 1-99 | clone B07a PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| A13 | codons 1-99 | clone A13 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| A11b | codons 1-99 | clone A11b PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| A02g | codons 1-99 | clone A02g PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| B06 | codons 1-99 | clone B06 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF >P21-16| codons 1-99 PQITLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYD QITIEICGHKAVGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Bacheler, LT | Human immunodeficiency virus type 1 mutations selected in patients failing efavirenz combination therapy. | AAC, 2000 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |