Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7126 | CA17603 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+D4T+IDV | 82 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, L90M | L10R, K20I, E35D, M36I, N37S, R57K, I62V, L63P, I64V, I72X, I93L, C95F |
| >CA17603| codons 1-99 PQITLWQRPRVTIKIGGQLIEALLDTGADDTVLEDISLPGRWKPKIIGGIGGFIKVKQYD QVPVEICGHKAXGTVLVGPTPVNIIGRNLMTQLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, T215Y | K43N, S68G, I135T, T200A, E203K, Q207E, I293V, E297K, V317A, I326V, I329V, G359S, A371V, T403M, E404D, L452M, V466I, S468P, L469I, L491S, K530R | F160FC, Y232Y*, L246LGRV |
| >CA17478| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELENEGKISKIGPENPYNTPV FAIKKKDGTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAICQSSMTKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIKELREHLLRWGFYTPDKKHQKEPPFLWMG*ELHPDKWT VQPIVVPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTKEAE LELAENREILKEPVHGAYYDPSKDLVAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRSA HTNDVKQLTEVVQKIATESIVIWGKTPKFKLPIQKETWEAWWMDYWQATWIPEWEFVNTP PLVKLWYQLEKEPIVGAETFYVDGAANRETKMGKAGYVTDRGRQKIVPITDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKERVYLAWVPAHK GIGGNEQVDKLVSAGIRKVL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |