Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2107 | CA17581 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | NA |
| 2 | D4T | 26 |
| 3 | 3TC+AZT | 21 |
| 4 | 3TC+AZT+RTV | 8 |
| 5 | 3TC+AZT+IDV | 17 |
| 6 | 3TC+NVP+SQV | 17 |
| 7 | D4T+DDI+NVP | 39 |
| 8 | 3TC+NVP+NFV | 56 |
| 9 | D4T+DDI | 8 |
| 10 | DDI | 12 |
| 11 | ABC+D4T+DDI | 72 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I15V, M36L, N37S, I62V, L63Q, I93L |
| >CA17581| codons 1-99 PQITLWQRPIVTIKVGGQLKEALLDTGADDTVLEELSLPGRWKPKMIGGIGGFIKVRQYD QVQIEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K43KE, E44A, V60I, V118I, I142V, D177E, I178M, H208HY, R211D, V245K, A272P, T286A, I293V | A299AG |
| >CA17456| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEEAGKISKIGPENPYNTPI FAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSIPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEMVI YQYMDDLYVGSDLEIGQHRTKIEELRQYLWDWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTEVVPLTEEGE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |