Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7088 | CA17556 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+AZT | 14 |
| 2 | 3TC+AZT+SQV | 12 |
| 3 | 3TC+AZT+IDV | 3 |
| 4 | 3TC+AZT | 23 |
| 5 | 3TC+AZT+NFV | 173 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| D30N | I15V, K20R, E35D, M36V, N37S, D60E, I62V, L63C |
| >CA17556| codons 1-99 PQITLWQRPLVTIKVGGQLREALLDTGADNTVLEDVSLPGRWKPKMIGGIGGFIKVRQYE QVCIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V | K102R, K122E, I135T, I178L, Q197K | T253TP, Q269QH |
| >CA17430| codons 1-277 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKRKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYVDDLYVGSDLEIGKHRTKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWPVNDIQKLVGKLNWASHIYAGIKVK |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |