<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
CA1148 CA17542 U.S. 2000 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 AZT 52
2 DDI+ AZT 91
3 SQV+ D4T+ 3TC 30
4 IDV+ DDI+ AZT 27
5 SQV+ RTV 8
6 SQV+ RTV+ AZT+ 3TC 59
7 SQV+ RTV+ D4T+ AZT+ 3TC 15
8 SQV+ NRTI+ D4T+ AZT+ 3TC+ ABC+ IDV 9
9 ABC+ IDV+ 3TC+ AZT+ RTV 51

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I54V, V82A, L90M F53L, G73S L10I, L33M, E34Q, N37HY, R57RK, Q61N, L63E, E65D, A71V  
>CA17542| codons 1-99
PQITLWQRPIVTIKIGGQLKEALLDTGADDTIMQEMHLPGRWKPKMIGGIGGLVKVKQYD
NIEIDICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, M184V, L210W, T215Y V75M, K219N     K20R, K43Q, E44D, V60I, K122E, D123X, I142V, S162Y, G196E, Q197K, E203D, H208F, R211K, S251I, A272P, I293V K281KE, A299AG
>CA17417| codons 1-300
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEQDGKISKIGPENPYNTPI
FAIKKKNSTRWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEXFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQYSMTKILEPFRKQNPDIVI
YQYVDDLYVGSDLEIEKHRTKIDELRQFLWKWGFYTPDNKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDIWTVNDIQKLVGKLNWASQIYPGIKVKQLCELLRGTKALTEVVPLTEEGE

References
Author Title Citation
Wu, TD Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. J Virol, 2003
Gonzales, MJ Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: Comparison of isolates from northern California with isolates from other regions. ARHR, 2003
Rhee, SY HIV-1 protease and reverse transcriptase mutations: Correlations with antiretroviral therapy in subtype B isolates and implications for drug-resistance surveillance. J Infect Dis, 2005