Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA5148 | CA17539 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT+3TC+IDV | 43 |
| 2 | 3TC+D4T+DDI+RTV | 21 |
| 3 | 3TC+DDI+RTV+SQV | 17 |
| 4 | 3TC+DDI+EFV | 34 |
| 5 | ABC+APV+D4T | 47 |
| 6 | 3TC+D4T+EFV+NFV | 23 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10I, K20R, E35D, M36I, N37D, D60E, I62V, L63P, A71X, V77I, I93L | R8RQ |
| >CA17539| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTVLEDIDLPGRWKPKMIGGIGGFIKVRQYE QVPIEICGHKXIGTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74V, M184V, T215F | K219W | K103N, Y181YC | V108VI | V35M, K43KE, I135T, E194EK, T200A, I202V, H208HY, R211K, I293V | A299AG |
| >CA17414| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICTELEEEGKISKIGPENPYNTPV FAIKKKNSDRWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTILDVGDAYFSVPL DKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI CQYVDDLYVGSDLKIGQHRAKVEELRQYLLKWGFFTPDWKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEGE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |