Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1271 | CA17509 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 52 |
| 2 | DDI | 52 |
| 3 | D4T | 100 |
| 4 | 3TC+AZT | 35 |
| 5 | 3TC+AZT+IDV | 22 |
| 6 | 3TC+D4T+IDV | 13 |
| 7 | 3TC+D4T+IDV+NVP | 4 |
| 8 | 3TC+RTV+SQV | 77 |
| 9 | 3TC+DDI+EFV+RTV+SQV+Unknown | 27 |
| 10 | DDI+EFV+Unknown | 1 |
| 11 | None | 5 |
| 12 | 3TC+RTV+SQV | 10 |
| 13 | Unknown | 68 |
| 14 | ABC+APV+DDC+LPV+TDF | 13 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, L90LM | G73GS | L10LI, K20KR, E35D, M36MI, N37E, R41K, L63P, K70KT, V77I, L89X, I93L |
| >CA17509| codons 1-99 PQITLWQRPIVTIKIGGQLREALLDTGADDTILEDIELPGKWKPKIVGGIGGFIKVRQYD QIPIEICGHTAISTVLIGPTPVNIIGRNXMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | V75VL, K219N | K103KN | K20R, T39A, E44D, V118I, K122E, I135T, D177E, H208Y, R211DN, L283I, R284K, I293V |
| >CA17385| codons 1-303 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICAELEKDGKISKIGPENPYNTPV FAIKKKNSTKWRKLLDFRELNKRTQDFWEVQLGIPHPAGLKKNKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKIEELRQYLWDWGFYTPDNKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLIKGTKALTEVVPLTEEAE LEL |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |