Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1600 | CA17508 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 260 |
| 2 | AZT+DDI | 47 |
| 3 | None | 13 |
| 4 | 3TC+AZT+SQV | 21 |
| 5 | 3TC+D4T+IDV | 52 |
| 6 | RTV+SQV | 4 |
| 7 | 3TC+AZT+NVP | 34 |
| 8 | 3TC+AZT | 17 |
| 9 | ADV+D4T+EFV+RTV+SQV | 69 |
| 10 | D4T+DDI+NVP | 31 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46MI, G48V, I54IT, V82VA | L10I, R57K, L63P, I64L, A71V, I72V, V77VI |
| >CA17508| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKIIVGIGGFTKVKQYD QIPLEICGHKVVGTVLIGPTPANIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74LI, M184V, L210W, T215Y | D67G | V35M, T39A, E40F, K43E, V60VI, S68G, R83RK, W88WC, K104R, V118I, K122E, D177N, T200A, R211K, K219X, L228H, T286A, E291D, E297K, A304G |
| >CA17384| codons 1-304 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALMEICAFLEEEGKISKIGPENPYNTPI FAIKKKGGTKWRKIVDFRELNKKTQDFCEVQLGIPHPAGLKKKRSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPNIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDXKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGAKALTDVIPLTKEAE LELG |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |