Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1497 | CA17491 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 152 |
| 2 | AZT+ DDI | 17 |
| 3 | 3TC+ AZT | 17 |
| 4 | AZT+ 3TC+ IDV | 34 |
| 5 | D4T+ DDI+ RTV | 43 |
| 6 | DDI+3TC+NVP+SQV+RTV+D4T | 13 |
| 7 | D4T+DDI+3TC+SQV+RTV | 76 |
| 8 | D4T+DDI+3TC+SQV | 39 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | Q58E, G73T | L10I, I13V, K20I, M36MI, F53Y, K55R, L63P, A71V | R8RQ |
| >CA17491| codons 5-99 LWQRPIVTVKIGGQLIEALLDTGADDTVLEEINLPGRWKPKIIGGIGGYVRVREYDQIPI EICGHKVITTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | A98G | K20R, V35I, K43E, E44D, V118I, D123E, I135T, D177E, T200K, Q207E, H208Y, R211K, K223Q, E248D, A272S, K277R, Q278QH, T286TA, I293V, A304G |
| >CA17357| codons 1-304 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALIEICTELEEDGKISKIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSIPL DKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRKKIEELREYLWKWGFYTPDKKHQQEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYSGIKVRHLCKLLRGAKALTEVVPLTEEAE LELG |
References
| Author | Title | Citation |
| Wu, TD | Mutation patterns and structural correlates in human immunodeficiency virus type 1 protease following different protease inhibitor treatments. | J Virol, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |