Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4914 | CA17483 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | NFV+ DDI+ D4T | 20 |
| 2 | SQV+ AZT+ RTV | 4 |
| 3 | 3TC+ AZT+ NFV+ NVP | 9 |
| 4 | 3TC+ NFV+ NVP | 16 |
| 5 | 3TC+ NVP | 26 |
| 6 | EFV | 8 |
| 7 | EFV+ ABC | 9 |
| 8 | IDV+ ABC+ 3TC+ RTV | 32 |
| 9 | APV+ AZT+ DDI | 35 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A | L10F | N37D, D60E, I62V, L63P, A71V, V77I, I93L |
| >CA17483| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVLEEMDLPGRWKPKIIGGIGGFVKVRQYE QVPIEICGHKVIGTVVIGPTPANIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41ML, T69S_SG, V75M, L210W, T215Y | Y188L | K122E, R172K, I178M, Q207E, R211K, A272P, K277R, T286A, A288AG, V292I | K281*L |
| >CA17367| codons 1-298 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPV FAIKKKDSSKWRKLMDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDMVI YQYMDDLLVGSDLEIGQHRTKIEELREHLWKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCLLLRGAKGLTEIIPLTEE |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |