Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7091 | CA17433 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | D4T+ 3TC+ IDV | 173 |
| 2 | D4T+ DDI+ EFV | 67 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | K219Q | L100I, K103N | K20R, K102R, I135V, I142V, Q174H, V179I, G196E, R211G, F214L, A272S, I293V, E297A | M16MIV, V254VG, A299AG |
| >CA17433| codons 1-303 PISPIETVPVKLKPGVDGPRVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPAGIKRNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKHNPDIII YQYMDDLYVGSDLEIEQHRTKIEELRQHLLGWGLFTPDQKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTGNDIQKLVGKLNWASQIYSGIKVKQLCKLLRGTKALTEVVPLTAEGE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10I, N37D, R41K, I62V, L63P, A71T, I72R, I93L, C95F |
| >CA17558| codons 1-99 PQITLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMDLPGKWKPKIIGGIGGFVKVRQYD QVPIEICGHKTRGTVLVGPTPANIIGRNLMTQLGFTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Colinearity of reverse transcriptase inhibitor resistance mutations detected by population-based sequencing. | JAIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |