Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA1802 | CA17429 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 104 |
| 2 | DDI | 104 |
| 3 | AZT+ 3TC | 104 |
| 4 | RTV+ D4T+ 3TC | 34 |
| 5 | SQV+ RTV+ DDI+ D4T | 47 |
| 6 | SQV+ RTV+ EFV+ D4T+ ADV+ 3TC | 21 |
| 7 | 3TC+ ADV+ EFV+ D4T | 4 |
| 8 | 3TC+ ADV+ EFV+ D4T+ RTV+ SQV | 42 |
| 9 | RTV+ SQV+ 3TC+ EFV+ D4T | 8 |
| 10 | SQV+ EFV+ D4T+ 3TC | 7 |
| 11 | None | 21 |
| 12 | 3TC+ EFV+ SQV+ D4T+ NRTI | 17 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, T215Y | K101P, K103N | K20R, V60I, S68G, V118I, D121H, K122E, I135K, D177E, I202V, R211K, V245E, E291D, V292I, I293V, A304G | S48V, K281KE |
| >CA17429| codons 1-304 PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALVEICTELEKEGKIVKIGPENPYNTPI FAIKKKDGTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLPKNKSVTVLDVGDAYFSIPL HEDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIGQHRTKVEELRQHLLKWGFYTPDKKHQKEPPFLWMGYELHPDKWT VQPIELPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCELLRGTKALTDIVPLTEEAE LELG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V | L24I | L10I, T12P, K14R, L63P, A71I, V77I |
| >CA17555| codons 1-99 PQITLWQRPIVPIRIGGQLKEALIDTGADDTVLEEMNLPGRWKPKMIGGIGGFVKVRQYD QIPIEICGHKIIGTVLIGPTPANVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Melikian, GL | Standardized comparison of the relative impacts of HIV-1 reverse transcriptase (RT) mutations on nucleoside RT inhibitor susceptibility. | AAC, 2012 |