Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4060 | CA17428 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 78 |
| 2 | 3TC+AZT | 178 |
| 3 | 3TC+ABC+AZT | 58 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, T215F | K219Q | A98G | V60I, I135V, D177E, G196E, D218E, V245T, I293V, I326LV, I329V, A371V, T386I, T403R, V435VI, V467VI, L491LS, V531I, A534AS, A554T | D256DV, K390Q |
| >CA17428| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIVI YQYVDDLYVGSDLEIEQHRTKIEELRQHLLRWGFFTPEQKHQKEPPFLWMGYELHPDKWT VQPITLPEKDSWTVNVIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTEEAE LELAENREILKEPVHGVYYDPSKDLVAEVQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTEVVQKIATESIVIWGKIPKFQLPIQKETWEAWWREYWQATWIPEWEFVNTP PLVKLWYQLEKEPIIGAETFYVDGAANRETKLGKAGYVTDRGRQKVISLTDTTNQKTELQ AIHLALQDSGSEVNIVTDSQYALGIIQAQPDKSESELVSQIIEQLIKKEKIYLSWVPAHK GIGGNEQVDKLVSTGIRKVL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, G16E, E35D, N37NS, I62V, L63P |
| >CA17553| codons 1-99 PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEDMSLPGRWKPKMIGGIGGFIKVRQYD QVPIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |
| Rhee, SY | Predictive Value of HIV-1 Genotypic Resistance Test Interpretation Algorithms. | J Infect Dis, 2009 |