Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA3898 | CA17413 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | IDV | 26 |
| 2 | D4T+DDI+NFV | 13 |
| 3 | D4T+DDI+SQV | 69 |
| 4 | D4T+DDI+APV | 9 |
| 5 | EFV+AZT+D4T+APV+RTV | 21 |
| 6 | 3TC+AZT+D4T+LPV | 20 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, M184V, T215F | K219Q | Y188L | A98G | V60I, I142V, I202V, V245M, A272P, V276T, I293V, E297A | A299AG |
| >CA17413| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPI FAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHPGGLKKKKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI YQYVDDLLVGSDLEIGQHRTKVEELRQHLLRWGFFTPDQKHQKEPPFLWMGYELHPDKWT VQPIMLPEKDSWTVNDIQKLVGKLNWASQIYPGIKTKQLCKLLRGTKALTEVVPLTAEGE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54L, I84V, L90M | L10F, L33F, G73S | E34EK, L63P, A71V, I72V, V77I |
| >CA17538| codons 1-99 PQITLWQRPFVTIKIGGQLKEALLDTGADDTVFKEMNLPGRWKPKMIGGIGGFLKVRQYD QIPIEICGHKVVSTVLIGPTPVNVIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |