Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA2197 | CA17405 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 112 |
| 2 | 3TC+ AZT+ RTV | 39 |
| 3 | 3TC+ D4T+ IDV | 100 |
| 4 | None | 5 |
| 5 | IDV+ D4T+ 3TC+ NVP | 43 |
| 6 | IDV+ D4T+ 3TC+ NVP+ RTV | 10 |
| 7 | D4T+ IDV+ NVP+ RTV+ ABC+ EFV | 1 |
| 8 | D4T+ ABC+ EFV | 28 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_SS, K70R, M184MV | A62V | K103N | A98S, D123E, I135IV, D177E, I178L, G196R, Q207E, R211K, V245K, A272P, K277R, I293V | A267AG, A299AG |
| >CA17405| codons 1-300 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FVIKKKDSSRWRKLVDFRELNKRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPELVI YQYVDDLYVGSDLEIRQHRTKIEELREHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIKLPEKDSWTVNDIQKLVGKLNWGSQIYPGIKVRQLCKLLRGTKALTEVVPLTEEGE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G73S | I15V, Q18H, K20M, M36I, L63P, H69Q, V77I, I85V, I93L |
| >CA17530| codons 1-99 PQITLWQRPLVTIKVGGHLMEALLDTGADDTVLEEINLPGRWKPKMIGGIGGFIKVRQYD QIPIEICGQKAISTVLIGPTPVNIVGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |