Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7066 | CA17393 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC | 29 |
| 2 | 3TC+AZT | 13 |
| 3 | 3TC+AZT+IDV | 22 |
| 4 | DDI+NFV+NVP | 20 |
| 5 | RTV+SQV | 48 |
| 6 | ABC+D4T+EFV | 73 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67DN, L210LW, T215F | K103N, Y181C | V179F | K49KR, K82R, A98S, D177E, G196E, Q207K, R211A, H221HY, L228LR, A272P, I293V | A299AG |
| >CA17393| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTELEKEGKISRIGPENPYNTPV FAIKKKNSTKWRKLVDFRELNRRTQDFWEVQLGIPHPSGLKKNKSVTVLDVGDAYFSVPL DKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPEIFI CQYMDDLYVGSDLEIEQHRTKIEELRKHLWAWGFFTPDKKYQKEPPFRWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTEEGE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V | L24LI | A22V, E35D, M36I, R57K, I62V, L63P, A71V, I72V, I93L |
| >CA17518| codons 1-99 PQITLWQRPLVTIKIGGQLKEVLIDTGADDTVLEDINLPGRWKPKIIGGIGGFIKVKQYD QVPIEICGHKVVGTVLVGPTPVNVIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |