Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA4351 | CA17377 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | 3TC+ AZT | 34 |
| 2 | 3TC+ AZT+ IDV | 21 |
| 3 | DDI+ IDV | 47 |
| 4 | D4T+ 3TC+ RTV+ SQV | 70 |
| 5 | ABC+ AZT+ 3TC | 11 |
| 6 | ABC+ DDI+ EFV | 52 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K103N | R83K, V90I, K102R, D123E, T139M, I178L, R211K, I293V, E297A | A299AG |
| >CA17377| codons 1-303 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKKTQDFWEIQLGIPHPAGLKRNKSVTVLDVGDAYFSVPL DKEFRKYTAFTIPSINNEMPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRTKIEELRQHLLKWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYAGIKVKQLCKLLRGTKALTEVVPLTAEGE LEL |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| E21EK, E35D, I62V, L63P, I64L, I93L | R8RQ |
| >CA17502| codons 1-99 PQITLWQRPLVTIKIGGQLKKALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QVPLEICGHKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Gonzales, MJ | Protease and reverse transcriptase mutation patterns in HIV-1 isolates from heavily treated persons: comparison of isolates from northern California with isolates from other regions. | ARHR, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |