Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| CA7052 | CA17358 | U.S. | 2000 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | AZT | 4 |
| 2 | DDI+ D4T | 134 |
| 3 | DDI+ D4T | 37 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65KR, Q151M | A62V, V75I, F77L | A33V, V35T, S68G, K122E, D123N, I178L, T200A, H221HY, E248D, A272P, Q278QE, I293V, A304G | A299AG |
| >CA17358| codons 1-304 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKVLTEICTEMEKEGKISKIGPENPYNTPV FVIKRKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DENFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSPAIFQSSMTKILEPFRKQNPDLVI YQYMDDLYVGSDLEIGQHRAKIEELRQHLLRWGFTTPDKKYQKEPPFLWMGYELHPDKWT VQPIVLPDKDSWTVNDIQKLVGKLNWASQIYPGIKVKELCKLLRGTKALTEVVPLTEEGE LELG |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I15V, G16E, E35D, I62V, L63Q |
| >CA17492| codons 1-99 PQITLWQRPLVTIKVEGQLKEALLDTGADDTVLEDMNLPGRWKPKMIGGIGGFIKVRQYD QVQIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Gonzales, MJ | Colinearity of reverse transcriptase inhibitor resistance mutations detected by population-based sequencing. | JAIDS, 2003 |
| Gonzales, MJ | Extended spectrum of HIV-1 reverse transcriptase mutations in patients receiving multiple nucleoside analog inhibitors. | AIDS, 2003 |
| Rhee, SY | HIV-1 Protease and Reverse Transcriptase Mutations: Correlations with Antiretroviral Therapy in Subtype B Isolates and Implications for Drug-Resistance Surveillance. | J Infect Dis, 2005 |