Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 96BW11 | 96BW11 | Botswana | 1997 | HIV1 | C | PBMC | MMC |
Treatment History
| Order | Regimen | Weeks |
| 1 | None | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| T12S, I15V, L19I, M36I, R41K, K43R, L63P, H69K, I93L |
| >96BW11| 6 | codons 1-99 | clone 6 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWRPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >96BW11| 4 | codons 1-99 | clone 4 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWRPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF >96BW11| B1 | codons 1-99 | clone B1 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWRPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLDF >96BW11| codons 1-99 PQITLWQRPLVSIKVGGQIKEALLDTGADDTVLEEINLPGKWRPKMIGGIGGFIKVRQYD QIPIEICGKKAIGTVLVGPTPVNIIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| V35T, E36A, T39E, S48T, K122E, D123S, A158S, K173A, Q174K, D177E, I178L, T200A, K201R, Q207K, P243S, V245K, D250E, A272P, I274V, K277R, T286A, E291D, V292I, I293V, Q334G, G335D, R356K, G359T, A376S, T377M, T386I, K390R, T397A, E404D, K431T, I434M, V435A, L452I, R461K, S468T, D471E, T477A, H483Q, L491P, S519N, A534S, Q547K, A554S |
| >96BW11| 6 | codons 1-560 | clone 6 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAKNPELVI YQYMDDLYVGSDLEIGQHRAKIEELRKHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQSIKLPEKESWTVNDIQKLVGKLNWASQIYPGVKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGGDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKISMESIVIWGKIPKFRLPIQKEAWEAWWTDY*QATWIPEWEFVNTP PLVKLWYQLETEPMAGAETFYVDGAANRETKIGKAGYVTDKGRQKVVTLTETTNQKAELQ AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEKVDKLVSSGIRKVL >96BW11| B1 | codons 1-560 | clone B1 PISPIETVPVKLKTGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPGNPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKHTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRAKNPELVI YQYMDDLYVGSDLEIGQHRARIEELRNHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQSIKLPEKESWTVNDIQKLVGKLNWASQIYPGVKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGGDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKISMESIVIWGKIPKFRLPIQKEAWEAWWTDYWQATWIPEWEFVNTP PLVKLWYQLETEPMAGAETFYVDGAANRETKIGKAGYVTDKGRQKVVTLTETTNQKAELQ AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEKVDKLVSSGIRKVL >96BW11| 4 | codons 1-560 | clone 4 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAKNPELVI YQYMDDLYVGSDLEIGQHRARIEELRKHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQSIKLPEKESWTVNDIQKLVGKLNWASQIYPGVKVRQLCKLLRGAKALTDIVPPTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGGDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKISMESIVIWGKIPKFRLPIQKEAWEAWWTDYWQATWIPEWEFVNTP PLVKLWYQLETEPMAGAETFYVDGAANRETKIGKAGYVTDKGRQEVVTLTETTNQKAELQ AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEKVDKLVSSGIREVL >96BW11| codons 1-560 PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALTAICEEMEKEGKITKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL DESFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPSIFQSSMTKILEPFRAKNPELVI YQYMDDLYVGSDLEIGQHRARIEELRKHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT VQSIKLPEKESWTVNDIQKLVGKLNWASQIYPGVKVRQLCKLLRGAKALTDIVPLTEEAE LELAENREILKEPVHGVYYDPSKDLIAEIQKQGGDQWTYQIYQEPFKNLKTGKYAKMRTA HTNDVKQLTEAVQKISMESIVIWGKIPKFRLPIQKEAWEAWWTDYWQATWIPEWEFVNTP PLVKLWYQLETEPMAGAETFYVDGAANRETKIGKAGYVTDKGRQKVVTLTETTNQKAELQ AIQLALQDSGPEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLSWVPAHK GIGGNEKVDKLVSSGIRKVL |
Integrase Sequence
| INIMajorDRMs | INIMinorDRMs | Polys | UnusualMuts |
| D25E, V31I, M50I, I72V, F100Y, L101I, T112I, T124A, T125A, K136Q, V201I, I203M, T218I, L234I, A265V, D278A | S283G |
| >96BW11| 1 | codons 1-288 | clone 1 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKIIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDMIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED >96BW11| 2 | codons 1-288 | clone 2 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKIIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEYLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDMIATDIQTRELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED >96BW11| 3 | codons 1-288 | clone 3 FLDGIDKAQEEHEKYHSNRRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKIIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSARERIIDMIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED >96BW11| codons 1-288 FLDGIDKAQEEHEKYHSNWRAMASEFNLPPIVAKEIVASCDKCQLKGEAIHGQVDCSPGI WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYYILKLAGRWPVKIIHTDNGSN FTSAAVKAACWWAGIQQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV FIHNFKRKGGIGGYSAGERIIDMIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGADCVAGRQDED |
References
| Author | Title | Citation |
| Novitsky, VA | Molecular cloning and phylogenetic analysis of human immunodeficiency virus type 1 subtype C: a set of 23 full-length clones from Botswana. | J Virol, 1999 |