<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method

Treatment History
Order Regimen Weeks
1 Unknown NA

Integrase Sequence
INIMajorDRMs INIMinorDRMs Polys UnusualMuts
  F121L E11D, S24H, V32I, D41N, M50I, I60V, I72V, L101I, T112I, T124A, G134D, K136Q, D167E, I203M, T218I, L234I S283G
>KS069| codons 1-288
FLDGIDKAQEDHEKYHSNWRAMAHDFNLPPVIAKEIVASCNKCQLKGEAIHGQVDCSPGV
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFILKLAGRWPVKIIHTDNGSN
LTSATVKAACWWADIQQEFGIPYNPQSQGVVESMNKELKKIIGQVREQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDMIATDIQTKELQKQIIKIQNFRVYYRDSRDPIWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVAGRQDED

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
    G16E, K20R, E35D, M36I, R41K, I62V, L63T, E65D, H69K, L89M  
>KS069| codons 1-99
PQITLWQRPLVTIKIEGQLREALLDTGADDTVLEDINLPGKWKPKMIGGIGGFIKVRQYD
QVTIDICGKKAIGTVLVGPTPVNIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
        K20R, V35T, T39K, E40D, V60I, D121H, I142V, T165I, K173S, D177E, G196E, Q207A, V245E, D250E, S251I, A272P, T286A, E291D, V292I, I293V, P294T, T296S, E297K, E312D, M357R, G359S, A371V, I375V, A376V, K390R, E399D, A400T, T403M, V435M, F440Y, V466I, V467I, D471E, Q480H, L491A, K512R, S519N, Q524K, K527E, A534S, A554N  
>KS069| codons 1-560
PISPIETVPVKLKPGMDGPRVKQWPLTEEKIKALTEICKDMEKEGKISKIGPENPYNTPI
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
HKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQSSMIKILEPFRSQNPEIVI
YQYMDDLYVGSDLEIEQHRTKIEELRAHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIELPEKEIWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGAKALTDIVTLSKEAE
LELAENREILKDPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARRRSA
HTNDVKQLTEVVQKVVTESIVIWGKTPKFRLPIQKETWDTWWMEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIMGAETYYVDGAANRETKLGKAGYVTDRGRQKIISLTETTNQKTELH
AIHLALQDSGAEVNIVTDSQYALGIIQAQPDRSESELVNQIIEKLIEKEKVYLSWVPAHK
GIGGNEQVDKLVSNGIRKVL

References
Author Title Citation
Vidal, N Genetic characterization of eight full-length HIV type 1 genomes from the Democratic Republic of Congo (DRC) reveal a new subsubtype, A5, in the A radiation that predominates in the recombinant structure of CRF26_A5U. ARHR, 2009